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What’s the difference between API General Cure and Seachem ParaGuard?

API General Cure and Seachem ParaGuard are both water treatments that you can use to help your sick fish recover. So, what are the main differences between these products?

You can find out in this article at Aquarium Blueprints.

Quick Summary

Both API General Cure and Seachem ParaGuard can be used to treat velvet, fill flukes and skin flukes. With that said, General Cure is a lot quicker at threating these infections when compared to ParaGuard. Not to mention that it is a lot less complicated to use General Cure than the other product.

Unlike the other product in this comparison, API General Cure will also treat Fish Lice and Hole-in-the-head.

On the other hand, Seachem ParaGuard is the only one of the two to treat Ich and Fin Rot.

API General Cure vs. Seachem ParaGuard Comparison Chart

You can take a look at our comparison table for the General Cure and ParaGuard below.

 API General CureSeachem ParaGuard
Infection Treatments Fish Lice

Gill Flukes (Dactylogyrus)

Hole-in-the-head Disease (Hexamita spp. and Spironucleus)

Skin Flukes (Gyrodactylus)

Velvet
Freshwater Ich (Ichthyophthirius)

Saltwater Ich (Cryptocaryon)

Freshwater Velvet (Piscinoodinium)

Saltwater Velvet (Amyloodinium)

Fin Rot

Gills Flukes (Monogenenean trematodes)

Skin Flukes (Dactylogyrus trematodes)
Treatment Length Fish Lice: 5 days

Gill flukes (Dactylogyrus): 5 days

Hole-in-the-head Disease (Hexamita spp. and Spironucleus): 5 days

Skin Flukes (Gyrodactylus): 5 days

Velvet: 5 days
Freshwater Ich (Ichthyophthirius): 14 days

Saltwater Ich (Cryptocaryon): 28 days

Freshwater Velvet (Piscinoodinium): 14 to 21 days

Saltwater Velvet (Amyloodinium): 14 to 21 days

Fin Rot: 7 days or until infection is cured

Gills Flukes (Monogenenean trematodes): 14 days or until infection no longer appears

Skin Flukes (Dactylogyrus trematodes): 14 days or until infection no longer appears
Dosage Instructions Packets Version: 1 full packet for every 10 gallons (or 38 liters)

Bulk Powder Version: 5 mL of General Cure for every 20 gallons (or 75 liters)
5 mL for every 10 gallons (or 40 liters)
Dosage Frequency Twice during treatmentDaily during treatment
After Treatment Removal Activated carbon and water changesActivated carbon and water changes
PricingCheck price on Amazon.Check price on Amazon.

Infection Treatments

Aside from Velvet and Flukes, the two treatments are designed to treat different infections.

You can find the full lists below:

API General Cure:

  • Fish Lice
  • Gill Flukes (Dactylogyrus)
  • Hole-in-the-head Disease (Hexamita spp. and Spironucleus)
  • Skin Flukes (Gyrodactylus)
  • Velvet

Seachem ParaGuard:

  • Freshwater Ich (Ichthyophthirius)
  • Saltwater Ich (Cryptocaryon)
  • Freshwater Velvet (Piscinoodinium)
  • Saltwater Velvet (Amyloodinium)
  • Fin Rot
  • Gills Flukes (Monogenenean trematodes)
  • Skin Flukes (Dactylogyrus trematodes)

Treatment Length

With General Cure, the treatment length for all infections is just 5 days, which is a lot sooner than ParaGuard.

For the Seachem product, the length can take anywhere from 7 to 28 days depending on the infection you are trying to treat as well as the type tank water.

You can take a look at the treatment lengths below:

API General Cure:

  • Fish Lice: 5 days
  • Gill flukes (Dactylogyrus): 5 days
  • Hole-in-the-head Disease (Hexamita spp. and Spironucleus): 5 days
  • Skin Flukes (Gyrodactylus): 5 days
  • Velvet: 5 days

Seachem ParaGuard:

  • Freshwater Ich (Ichthyophthirius): 14 days
  • Saltwater Ich (Cryptocaryon): 28 days
  • Freshwater Velvet (Piscinoodinium): 14 to 21 days
  • Saltwater Velvet (Amyloodinium): 14 to 21 days
  • Fin Rot: 7 days or until infection is cured
  • Gills Flukes (Monogenenean trematodes): 14 days or until infection no longer appears
  • Skin Flukes (Dactylogyrus trematodes): 14 days or until infection no longer appears

Dosage Instructions

When it comes to dosage, you need to add 1 full packet for every 10 gallons (or 38 liters) of tank water if you have the normal version of API General Cure. If you have the bulk powder version, then you need to add 5 mL of General Cure for every 20 gallons (or 75 liters) of tank water.

As for Seachem ParaGuard, you need to add 5 mL for every 10 gallons (or 40 liters) of tank water.

Dosage Frequency

When it comes to dosing frequency, you only need to dose API General Cure twice with the first dose at the start and then the next dose being 48 hours later.

With Seachem ParaGuard, you need dose daily for the duration of the treatment length.

After Treatment Removal

Once you are done treating your fish, you can get rid of both API General Cure and Seachem ParaGuard from your tank water by doing water changes.

Adding activated carbon will also help as this chemical filter media will absorb the medications.

If ParaGuard doesn’t seem to be helping your sick fish heal, then you can take a look at this troubleshooting article.