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What’s the difference between API General Cure and Seachem Metroplex

API General Cure and Seachem Metroplex are two similar treatments you can use in your fish tank. So, what are the main differences between these products?

You can find out in this versus guide at Aquarium Blueprints.

Quick Summary

Although API General Cure and Seachem Metroplex can both be used to treat Hole-in-the-Head Disease and Velvet, you will get much faster results with General Cure.

The API product is also the only one in this comparison that can be used to treat Fish Lice, Gill Flukes and Skin Flukes. On the other hand, Metroplex is the only one out of these two products that will also treat Ich.

API General Cure vs. Seachem Metroplex Comparison Chart

You can check out our comparison table between the API General Cure and Seachem Metroplex below.

 API General CureSeachem Metroplex
Infection Treatments Fish Lice

Gill Flukes (Dactylogyrus)

Hole-in-the-head Disease (Hexamita spp. and Spironucleus)

Skin Flukes (Gyrodactylus)

Velvet
Hole-in-the-head Disease (Hexamita spp. and Spironucleus)

Ich

Velvet
Treatment Length Fish Lice: 5 days

Gill flukes (Dactylogyrus): 5 days

Hole-in-the-head Disease (Hexamita spp. and Spironucleus): 5 days

Skin Flukes (Gyrodactylus): 5 days

Velvet: 5 days
Hole-in-the-head Disease (Hexamita spp. and Spironucleus): 14 days

Ich: 14 days to 28 days

Velvet: 14 days to 28 days
Dosage Instructions Packets Version: 1 full packet for every 10 gallons (or 38 liters)

Bulk Powder Version: 5 mL of General Cure for every 20 gallons (or 75 liters)
1 to 2 scoops for every 10 gallons (or 40 liters)
Dosage Frequency Twice during treatmentEvery 48 hours during the entire treatment length
After Treatment Removal Activated carbon and water changesActivated carbon and water changes
PricingCheck price on Amazon.Check price on Amazon.

Treatable Infections

Both of these products can be used to treat Hole-in-the-head Disease and Velvet.

General Cure is the only product in this comparison that will also treat Fish Lice, Gill Flukes and Skin Flukes. On the other hand, Metroplex is the only one of the two to treat Ich.

You can find a breakdown of the treatable infections for both below:

API General Cure:

  • Fish Lice
  • Gill Flukes (Dactylogyrus)
  • Hole-in-the-head Disease (Hexamita spp. and Spironucleus)
  • Skin Flukes (Gyrodactylus)
  • Velvet

Seachem Metroplex:

  • Hole-in-the-head Disease (Hexamita spp. and Spironucleus)
  • Ich
  • Velvet

Treatment Length

API General Cure is designed to work quickly as you can be done with your treatment in just 5 days. In comparison, Metroplex will take at least 14 days.

You can find the recommended treatment lengths for each infection below:

API General Cure:

  • Fish Lice: 5 days
  • Gill flukes (Dactylogyrus): 5 days
  • Hole-in-the-head Disease (Hexamita spp. and Spironucleus): 5 days
  • Skin Flukes (Gyrodactylus): 5 days
  • Velvet: 5 days

Seachem Metroplex:

  • Hole-in-the-head Disease (Hexamita spp. and Spironucleus): 14 days
  • Ich: 14 days to 28 days
  • Velvet: 14 days to 28 days

Dosage Instructions

When it comes to how much you should be dosing, you need to add 1 full packet for every 10 gallons (or 38 liters) of tank water if you are using General Cure. If you have the bulk powder version of General Cure, then you need to add 5 mL for every 20 gallons (or 75 liters) of tank water.

For the Metroplex, you need to dose 1 to 2 scoops per every 10 gallons (or 40 liters) of tank water.

Dosage Frequency

For the dosing frequency, you only need to dose API General Cure twice at 48 hours apart.

For Seachem Metroplex, you need to dose every 48 hours for the entire duration of the treatment.

After Treatment Removal

Once you are done treating your aquarium with both of the medications, you can remove them from the water column by adding activated carbon to your fish tank filter.

Doing water changes will also help dilute General Cure and Metroplex from your tank water.

If you fish aren’t eating food when you are treating them with API General Cure, then you can take a look at this troubleshooting article to see what steps you can take.

To see how you can use Metroplex together with Kanaplex, you can check out this guide.